维生素A是指具有视黄醇生物活性的一类脂溶性维生素，主要包括视黄醇及其酯类和视黄酸及其盐类两种活性亚型。

其中，视黄酸(又名维甲酸)为化妆品中禁用组分。视黄醇及其酯类能促进表皮基底层的角质形成细胞增殖,能激发前胶原分子的合成，同时促进已角化的角质细胞脱落，从而改善皮肤光滑度，发挥祛皱功效；可抑制基质金属蛋白酶被紫外线过度激发的活性，减少对胶原纤维的破坏，防止光老化；能抑制黑色素形成，在美白提亮方面颇有成效。因此视黄醇及其酯类被广泛应用于抗皱、祛痘以及美白化妆品中。

Vitamin A refers to a class of lipid soluble vitamins with biological activity of retinol, mainly including two active subtypes: retinol and its esters, and retinoic acid and its salts.

Among them, retinoic acid (also known as retinoic acid) is a prohibited component in cosmetics. Retinol and its esters can promote the proliferation of keratinocytes in the basal layer of the epidermis, stimulate the synthesis of procollagen molecules, and promote the shedding of keratinized cells, thereby improving skin smoothness and exerting wrinkle removing effects; Can inhibit the activity of matrix metalloproteinases excessively stimulated by ultraviolet light, reduce damage to collagen fibers, and prevent photoaging; It can inhibit the formation of melanin and is quite effective in whitening and brightening. Therefore, retinol and its esters are widely used in anti wrinkle, acne removal, and whitening cosmetics.

化妆品中常见维生素A超量摄入的影响

The impact of excessive intake of common vitamin A in cosmetics

拉姆化妆品检测温馨提醒：如果维生素A的超量摄入会引发皮肤问题及中毒现象，甚至可能导致婴儿畸形，拉姆化妆品检测评估其在化妆品中使用的安全性，并提出视黄醇及其酯类在身体乳液中的安全使用量为0.05%,在其他驻留类和淋洗类化妆品中的安全使用量为0.3%。

Ramertest Cosmetics Testing Tips: If the excessive intake of vitamin A will cause skin problems and poisoning, and may even lead to infant malformations, Lam Cosmetics Testing evaluates the safety of its use in cosmetics, and proposes that the safe use of retinol and its esters in body lotion is 0.05%, and the safe use of retinol and its esters in other resident and rinsing cosmetics is 0.3%.

《已使用化妆品原料目录(2021年版)》相关规定

Relevant provisions of the Catalogue of Used Cosmetic Raw Materials (2021 Edition)

我国发布的《已使用化妆品原料目录(2021年版)》载明，视黄醇在驻留类化妆品中的最高历史使用量为1%,视黄醇乙酸酯和视黄醇棕榈酸酯的最高历史使用量分别高达5.5%和5%,显然过量使用该类物质存在较大的安全风险。

The "Catalogue of Used Cosmetic Raw Materials (2021 Edition)" released by China states that the highest historical usage of retinol in resident cosmetics is 1%, and the highest historical usage of retinol acetate and retinol palmitate are 5.5% and 5%, respectively. Obviously, excessive use of these substances poses significant safety risks.

拉姆化妆品检测——化妆品中常见维生素A的检测方法

Ramertest Cosmetics Testing Method for Common Vitamin A in Cosmetics

拉姆化妆品检测实验室采用高效液相色谱法(HPLC)进行化妆品中维生素A、维生素A醋酸酯和维生素A棕榈酸酯测定，同时拉姆化妆品检测实验室也采用超临界色谱法建立了化妆品中维生素A类衍生物、维生素D2和维生素D3的同时检测方法。

The Ramertest Cosmetics Testing Laboratory used high-performance liquid chromatography (HPLC) to determine vitamin A, vitamin A acetate, and vitamin A palmitate in cosmetics. The Ram Cosmetics Testing Laboratory also established a simultaneous detection method for vitamin A derivatives, vitamin D2, and vitamin D3 in cosmetics using supercritical chromatography.

拉姆化妆品检测——业务范围

Ramretest Cosmetics Testing Business Scope

拉姆化妆品检测——工作流程

Ramertest  Cosmetics Testing Workflow